LC/MS/MS in drug development: targeting the brain

LC/MS/MS in drug development: targeting the brain.

INTRODUCTION Success of drug development generally relies on selecting one or two most drug-like molecules from a large number of new chemical entities (NCEs) generated by combinatorial chemistry and subsequently filtered using in silico predictions. Drug-like properties include reliable bioactivity, favorable physical-chemical properties, and acceptable drug metabolism and pharmacokinetic (DMP...

Drug targeting to the brain

Many brain diseases (such as meningitis, encephalitis, multiple sclerosis (MS), stroke, brain tumors, epilepsy, Alzheimer's disease, AIDS related dementia, Parkinson's disease) are under treated or cannot be treated at all due to the presence of the barriers in the brain (blood-brain barrier, blood-cerebrospinal fluid barrier and the braincerebrospinal fluid barrier). The blood-brain barrier is...

Drug targeting to the diseased brain

The delivery of hydrophilic drugs to the brain is limited by the various barriers in the brain. In this respect, the blood-brain barrier (BBB) is the most important barrier because it functions as a physical and metabolic barrier represented by the endothelial cells of brain capillaries. In order to treat brain diseases, drugs must pass the BBB by targeting them to internalizing transport syste...

Mitochondrial Targeting for Drug Development

the survey of the virtual higher education in iran and the ways of its development and improvement

این پژوهش با هدف "بررسی وضعیت موجود آموزش عالی مجازی در ایران و راههای توسعه و ارتقای آن " و با روش توصیفی-تحلیلی و پیمایشی صورت پذیرفته است. بررسی اسنادو مدارک موجود در زمینه آموزش مجازی نشان داد تعداد دانشجویان و مقاطع تحصیلی و رشته محل های دوره های الکترونیکی چندان مطلوب نبوده و از نظر کیفی نیز وضعیت شاخص خدمات آموزشی اساتید و وضعیت شبکه اینترنت در محیط آموزش مجازی نامطلوب است.